Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia

Background Aspiration community-acquired pneumonia (ACAP) and (CAP) in patients with aspiration risk factors (AspRFs) are infections associated anaerobes, but limited evidence suggests their pathogenic role. Research Question What the factors, microbiology patterns, empiric anti-anaerobic use hospitalized CAP? Study Design Methods This is a secondary analysis of GLIMP, an international, multicenter, point-prevalence study adults CAP. Patients were stratified into three groups: (1) ACAP, (2) CAP/AspRF+ (CAP AspRF), (3) CAP/AspRF- without AspRF). Data on demographics, comorbidities, microbiological results, antibiotics analyzed all groups. further severe nonsevere CAP Results We enrolled 2,606 CAP, which 193 (7.4%) had ACAP. Risk independently ACAP male, bedridden, underweight, nursing home resident, having history stroke, dementia, mental illness, enteral tube feeding. Among non-ACAP patients, 1,709 (70.8%) 704 (29.2%) CAP/AspRF-. Microbiology patterns including anaerobes similar between CAP/AspRF-, (0.0% vs 1.03% 1.64%). higher rates total gram-negative bacteria (64.3% 44.3% 33.3%, P = .021) lower gram-positive (7.1% 38.1% 50.0%, < .001) when compared respectively. Most (>50% groups) independent AspRFs or received specific broad-spectrum coverage antibiotics. Interpretation Hospitalized anaerobic flora factors. Gram-negative more prevalent Despite groups, large proportion antibiotic coverage.